Abstract Laterite gravels have been successfully adopted as pavement materials in the field. Despite that, they are often rejected in material selection processes because of its base on traditional gradation and consistency limits requirements. To allow a deeper evaluation of such material found abundantly in tropical countries, along to characterizing traditional parameters, repeated load triaxial tests were performed in a Laterite Gravel from Acre/Brazil to evaluate its elastic and plastic behavior through Resilient Modulus (RM) and Permanent Deformation (PD), respectively. In addition, a simulation was conducted in the MeDiNa software, based on the test results considering stress states that are usually applied in pavement layers. The material showed RM values higher than 500 MPa, which was considered high compared to materials such as Quartz and Granite. It was also observed low permanent deformation (below 1 mm for higher tensions applied) and accommodation of displacement (shakedown) for most specimens. The simulation results showed low rutting prediction for the Laterite Gravel applied in highway pavement layers. Thus, the results indicated that the lateritic gravel can be adopted in the composition of base or subbase layers of flexible pavements, even though some limits of the parameters specified by traditional specifications were violated, as expected. In addition, we also highlight the need for adoption of new material selection strategies that are based on key mechanical characteristics to avoid discarding potentially well performing materials.

Resumo: Este trabalho tem como objetivo discutir a criação da Faculdade de Direito no Vale do Paraíba em 1954, na cidade de São José dos Campos. Por meio de depoimentos de pessoas que viveram nesse período e publicações de jornais, foi possível concluir que a Faculdade foi criada como consequência da vontade da elite local de criar uma instituição de ensino privada que melhorasse a imagem da cidade e dos atores locais.

Abstract: This work aims to discuss the creation of the Faculty of Law in the Vale do Paraíba in 1954, in the city of São José dos Campos. Through testimony from people who lived in this period and newspaper publications, it was possible to conclude that the Faculty was created as a consequence of the will of the local elite to create a private educational institution that would improve the image of the city and the local actors.

Resumen: Este trabajo tiene como objetivo discutir la creación de la Facultad de Derecho en el Vale do Paraíba en 1954, en la ciudad de São José dos Campos. Por medio de testimonios de personas que vivieron en ese período y publicaciones de periódicos, fue posible concluir que la Facultad fue creada como consecuencia de la voluntad de la élite local de crear una institución de enseñanza privada que mejorara la imagen de la ciudad y de los actores locales.

Résumé: Ce travail vise à discuter la création de la Faculté de Droit du Vale do Paraíba en 1954, dans la ville de São José dos Campos. Grâce à des témoignages de personnes qui vivaient à cette époque et à des publications de journaux, il a été possible de conclure que la Faculté était née de la volonté de l’élite locale de créer un établissement d’enseignement privé qui améliorerait l’image de la ville et des acteurs locaux.

The reactivation of Herpes Simplex virus (HSV) occurs in 70% to 80% of patients submitted to autologous stem cell transplantation (ASCT); it increases the severity of chemotherapy-induced mucositis. Therefore, the use of acyclovir in ASCT patients is considered standard practice. However, the minimum dose needed to prevent reactivation is a matter of debate. We compared two doses of acyclovir in a non-randomized fashion in 59 patients submitted to ASCT: 32 patients received a dose of 125 mg/m² IV every six hours and the subsequent 27 patients received a dose of 60 mg/m² IV every six hours. Viral excretion was evaluated through weekly viral culture of oral swabs. Grade 4 mucositis was more frequent in Group 1 (p= 0.03). The reactivation rates in Groups 1 and 2 were 9% and 4%, respectively (p= 0.62, 95% confidence interval -7 - 18). Prophylaxis with reduced doses of intravenous acyclovir seems to be as effective as a higher dose in inhibiting HSV reactivation, with a significant reduction in cost. Prospective randomized studies are needed to confirm our conclusions.